Multifocal acquired demyelinating sensory and motor neuropathy

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Multifocal acquired demyelinating sensory and motor neuropathy: report of a case and review of the literature.

Multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy is characterized by an asymmetric multifocal pattern of motor and sensory loss, and conduction block and other features of demyelination in nerve conduction studies. MADSAM neuropathy needs to be differentiated from chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). In classic CI...

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Antiganglioside antibodies in multifocal acquired sensory and motor neuropathy.

BACKGROUND Multifocal acquired demyelinating sensory and motor neuropathies are considered autoimmune and responsive to immunotherapy. In the absence of demyelination, however, they are considered idiopathic if no other cause is found. OBJECTIVE To determine whether patients with multifocal acquired sensory and motor neuropathy of an otherwise unknown cause have antiganglioside antibodies, re...

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Sensory pathophysiology in chronic acquired demyelinating neuropathy.

Pathophysiological changes in sensory fibres in chronic acquired demyelinating neuropathy (CADP) are poorly understood, and it is not known to what extent sensory loss may be due to axonal loss or to conduction block. Motor and sensory nerve condition were studied in 18 patients with CADP to delineate abnormalities in the compound sensory action potential (CSAP) recorded proximally along the li...

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Hemiatrophy of the Tongue with Contralateral Hemiparesis in a Patient with Multifocal Acquired Demyelinating Sensory and Motor Neuropathy

Dear Editor, Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM), also referred to as Lewis-Sumner syndrome, is an atypical form of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).1 Cranial nerves are involved in some MADSAM cases. We report a case of a patient with MADSAM who showed hemiatrophy of the tongue with contralateral hemiparesis. A 55-year-old Jap...

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Multifocal motor neuropathy.

We report the case of a patient with multifocal motor neuropathy. Electrophysiological studies showed typical multifocal conduction blocks, but the search for anti-GM1 antibodies was negative. This case provide the heterogeneity of this clinical entity.

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ژورنال

عنوان ژورنال: Neurology

سال: 2012

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0b013e31826e9b62